Seagate Technology has been granted a patent for a Surface-Enhanced Raman Spectroscopy (SERS) device that enables accurate label-free long-read DNA sequencing. The device uses a Raman sensor with plasmonic nanostructures to create a hot spot, where an immobilized DNA polymerase pulls a DNA template strand through for sequencing. The method involves passing the DNA strand through the hot spot, identifying nucleotides in different sections of the strand at different times using Raman signatures, and comparing the identified nucleotides to detect changes. GlobalData’s report on Seagate Technology gives a 360-degree view of the company including its patenting strategy. Buy the report here.
Smarter leaders trust GlobalData
According to GlobalData’s company profile on Seagate Technology, Artificial concrete aggregates was a key innovation area identified from patents. Seagate Technology's grant share as of September 2023 was 71%. Grant share is based on the ratio of number of grants to total number of patents.
Dna sequencing using surface-enhanced raman spectroscopy (sers) device
A recently granted patent (Publication Number: US11774366B2) describes a method and device for sequencing DNA strands using a Surface-Enhanced Raman Spectroscopy (SERS) sensor. The method involves passing the DNA strand through a nanochannel hot spot of the sensor, which is bounded by plasmonic nanostructures and excited by lasers. The nucleotides of different sections of the DNA strand are identified at different time periods using Raman signatures, and these identified nucleotides are compared to identify any changes.
The method can involve passing a DNA template strand through the nanochannel, which can be pulled via a DNA polymerase. The DNA polymerase can build a complementary strand from individual free nucleotides. Alternatively, the DNA strand can be pulled via a DNA exonuclease. The template DNA strand can be moved to the nanochannel using electrophoresis or magnetophoresis.
The SERS sensor described in the patent includes a sample loading channel, a secondary chamber with an immobilized DNA polymerase, and a nanochannel connecting the two. The nanochannel contains a SERS hot spot defined by plasmonic nanostructures, each excited by a laser. A Raman detector is connected to the SERS hot spot to measure Raman spectra from the nucleotides of the DNA strand. The sensor also includes a secondary chamber downstream of the SERS hot spot.
The patent also mentions the use of light filters connected to the Raman detector, four plasmonic nanostructures arranged as two pairs, and a waveguide optically connected to each of the plasmonic nanostructures.
Overall, this patent describes a method and device for sequencing DNA strands using a SERS sensor. The method involves passing the DNA strand through a nanochannel hot spot and identifying nucleotides using Raman signatures. The device includes a sample loading channel, a secondary chamber with an immobilized DNA polymerase, and a nanochannel with plasmonic nanostructures. This technology has the potential to advance DNA sequencing techniques and contribute to various fields such as genomics and personalized medicine.
To know more about GlobalData’s detailed insights on Seagate Technology, buy the report here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
