Cyberdyne has been granted a patent for a three-dimensional structuring method and system for cells. The method involves inserting fibers into a flow path, placing cell clusters in the flow path, and culturing the cell clusters on the outer surface of the fibers. The system ensures efficient bonding of multiple cell clusters while maintaining safety. The patent also includes claims for adjusting the flow rate, number, and timing of cell clusters in the flow path. A flat plate is provided as a growth support for the cultured cell clusters. GlobalData’s report on Cyberdyne gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Cyberdyne, exoskeleton robotics was a key innovation area identified from patents. Cyberdyne's grant share as of September 2023 was 49%. Grant share is based on the ratio of number of grants to total number of patents.
Three-dimensional cell culture method using fibers and flow path
A recently granted patent (Publication Number: US11746316B2) describes a three-dimensional culture method for cells. The method involves positioning a plurality of fibers in a flow path, where the fibers are aligned with the direction of the flow path and spaced apart. A culture solution is continuously supplied through the flow path, and cell clusters are placed in the flow path at specific intervals and allowed to flow with the culture solution. The cell clusters stack on the outer surface of the fibers and are cultured. The flow rate of the culture solution, the number of cell clusters, and the timing of their placement in the flow path can be adjusted. A flat plate is provided downstream of the flow path as a growth support for the cultured cell clusters.
In one embodiment, the fibers used in the method have hollow interiors or lateral grooves with micropores that allow for the removal of metabolic waste from the cell clusters. These fibers can also supply growth factors and nutritional factors to the cell clusters through the micropores.
The patent also mentions the ability to control various parameters of the culture solution, such as temperature, carbon dioxide concentration, oxygen concentration, and nitrogen concentration.
Additionally, the method involves applying vibration to the fibers at specific timings along the flow path direction to aid in the growth process of the cell clusters.
This three-dimensional culture method offers a novel approach to culturing cells by utilizing fibers in a flow path. The use of fibers allows for the stacking of cell clusters and provides a growth support surface. The ability to adjust the flow rate, number of cell clusters, and timing of their placement offers flexibility in the culture process. The inclusion of hollow fibers with micropores enables the removal of waste and the supply of growth factors and nutrients. The control of various parameters of the culture solution ensures optimal conditions for cell growth. The application of vibration further enhances the growth process. Overall, this patented method has the potential to advance cell culture techniques and contribute to various fields such as tissue engineering and regenerative medicine.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
